Isavuconazole is highly active in vitro against Candida species isolates but shows trailing effect
نویسندگان
چکیده
منابع مشابه
In Vitro Susceptibility and Trailing Growth Effect of Clinical Isolates of Candida Species to Azole Drugs.
BACKGROUND Emergence of resistance to respective antifungal drugs is a primary concern for the treatment of candidiasis. Hence, determining antifungal susceptibility of the isolated yeasts is of special importance for effective therapy. For this purpose, the clinical laboratory standard institute (CLSI) has introduced a broth microdilution method to determine minimum inhibitory concentration (M...
متن کاملin vitro susceptibility and trailing growth effect of clinical isolates of candida species to azole drugs
conclusions the monitoring of antifungal susceptibilities of candida species isolated from clinical sources is highly recommended for the efficient management of patients. moreover, the trailing effect should be taken into consideration once the interpretation of the results is intended. results among the tested antifungal drugs in this study, the highest rate of resistance was observed against...
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Isavuconazole is the active component of the new azole antifungal agent BAL8557, which is entering phase III clinical development. This study was conducted to compare the in vitro activities of isavuconazole and five other antifungal agents against 296 Candida isolates that were recovered consecutively from blood cultures between 1995 and 2004 at a tertiary care university hospital. Microdiluti...
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Background and Purpose: The incidence of invasive fungal infections has been increased in recent years. The growing use of azole drugs for prophylactic and therapeutic purposes has resulted in the gradual emergence of azole-resistant species. Accordingly, the introduction of a new strategy to improve the management of Candida infections is an urgent need. Regarding this, the present study was p...
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Pathogenic Candida species are widely distributed in human and animal hosts. Accordingly, they account for 88% of nosocomial fungal infections and are the fourth cause of hospital-acquired blood infections. Fresh Garlic (Allium sativum) contains a sulfur compound that is composed of an amino acid (cysteine) called Alliin. The compounds in garlic are divided into two groups of sulfur and nonsulf...
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ژورنال
عنوان ژورنال: Clinical Microbiology and Infection
سال: 2020
ISSN: 1198-743X
DOI: 10.1016/j.cmi.2020.07.023